Reduced function of hepatic OATP transport proteins Simtano especially this the systemic exposure of simvastatin and increase the risk of myopathy and rhabdomyolysis. All statins can cause muscle pain, but this effect is more likely with simvastatin use.
Possible side effects of Simtano include:
Simtano is used to treat diseases such as: Cardiovascular Risk Reduction, High Cholesterol, High Cholesterol, Familial Heterozygous, High Cholesterol, Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa, Elevated LDL, Hyperlipoproteinemia Type IIb, Elevated LDL VLDL, Hyperlipoproteinemia Type III, Elevated beta-VLDL IDL, Hyperlipoproteinemia Type IV, Elevated VLDL, Prevention of Cardiovascular Disease.
In severe refractory hypertension, daily doses of up to 2400 mg have been given, divided into three or four times a day regimens. Pediatric doses should not exceed recommended adult doses.